Mark Soloski, PhDProfessor Emeritus
- Ph.D.: Rutgers University, Thesis Title: Vaccinia Virus: Studies on DNA-protein interactions occurring in the cytoplasm of infected cells and in mature virions.
Dr. Soloski has a basic interest in the role that infection plays in setting the stage for chronic immune mediated inflammatory diseases. Recently he has begun to investigate the human host immune response to infection with Borrelia burgdorferi the causative agent of Lyme disease. His efforts will attempt to identify cellular and/or molecular immune biomarkers that associate with effectiveness of bacterial clearance and/or disease pathophysiology and employs genomic, proteomic and complex immune phenotyping approaches.
A second area of interest is the identification of immune targets in psoriatic arthritis and ankylosing spondylitis. He is utilizing samples from a well-characterized patient cohort to identify novel autoantigens. His approach is to utilize state of the art proteomic and phage display based systems.
Lastly he is interested in the role of cellular elements of the immune response in controlling infection with gram-negative bacterial pathogens such as Salmonella typhimurium. This interest is driven not only because these bacteria cause significant acute disease but also due to the etiological link between infection with Salmonella and related species with the development of chronic autoimmune disease.