Website: Recent Publications by Dr. Rosen
Dr. Antony Rosen is the Mary Betty Stevens Professor of Medicine, and Director of the Division of Rheumatology. He is also Professor of Pathology. Dr. Rosen graduated from the University of Cape Town Medical School, and pursued postdoctoral training at the Rockefeller University in New York. He did residency training on the Osler Medical service at Johns Hopkins Hospital, prior to pursuing rheumatology fellowship at Johns Hopkins.
Dr. Rosen’s research has been focused on the shared mechanisms of the autoimmune rheumatic diseases, including Sjogren’s syndrome, scleroderma, lupus, myositis, rheumatoid arthritis and vasculitis. Dr. Rosen’s work has been done in partnership with Dr. Casciola-Rosen, and they have together used the striking specificity of the immune responses in different phenotypes to define the circumstances in the target tissues in vivo which drive the ongoing immune response in these diseases. Their work has focused on the fate of autoantigens in the target cells damaged by the immune response during various physiological and inflammatory circumstances, including exposure to ultraviolet radiation, viral infection, interferon exposure, various types of cell death, and relevant immune effector pathways.
Dr. Rosen’s laboratory currently focuses on 2 exciting areas: (i) Defining the properties of autoantibodies which allow them to induce cellular or molecular dysfunction, and thereby amplify injury of specific tissues in different rheumatic diseases; and (ii) Understanding the mechanisms underlying the striking connections between autoimmunity and cancer, which many shed light on the events which cause and drive autoimmune diseases.
