![Hot spots in Topo protein drive shared autoimmune responses in scleroderma patients](https://www.hopkinsrheumatology.org/wp-content/uploads/2020/10/2020-10-22-Scleroderma-Protein.jpg)
Researchers at Johns Hopkins identified “hot spots” in the Topo protein that are targeted by the immune system in scleroderma patients with different genetic backgrounds, which may help us understand why the immune system attacks healthy tissues in this autoimmune disease.