Recognition of the EM rash is crucial to early diagnosis and treatment. Improved rash recognition using deep learning methodology to prescreen patient rash photos may help prevent later serious manifestations of Lyme disease.
PET Imaging of Glial Activation in Patients with Post Treatment Lyme Disease
This study uses a neuroimaging radiotracer with positron emission tomography (PET) to quantify cerebral glial activation in brains of patients with post-treatment Lyme disease. Results show elevated central nervous system immune activation in patients with PTLDS as compared to controls.
Myositis Patients, Caregivers, and Healthcare Providers Weigh-in About What is Most Important to Them
Our results indicate that substantial differences exist in how myositis is perceived by patients compared to healthcare providers, with different items prioritized.
Robust B Cell Responses Predict Rapid Resolution of Lyme Disease
Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant worldwide illness. This study provides insights into important immune mechanisms involved in Borrelia burgdorferi clearance in human Lyme disease.
Incidence of Lyme Disease Diagnosis in a Maryland Medicaid Population
This study evaluates overall incidence rates and demographic, seasonal, and geographic trends of first Lyme disease diagnosis among 384,652 Maryland Medicaid members enrolled from July 2004-June 2011 and represents the first analysis of claims data from publicly insured individuals.
Cognitive Decline in Post-treatment Lyme Disease Syndrome
Patients with Post-treatment Lyme Disease Syndrome (PTLDS) commonly complain of cognitive symptoms. The study found, in subsets of PTLDS patients, objective evidence of cognitive decline in verbal memory and processing speed, cognitive impairment, and sub-optimal engagement with testing.
Obstacles to Diagnosis and Treatment of Lyme Disease in the USA
To our knowledge, this is the first study to explore factors which may contribute to a delay in diagnosis and treatment of Lyme disease. We identified distinct, potentially modifiable risk factors between onset of first Lyme disease symptoms and treatment. Targeting these drivers may reduce time to diagnosis and treatment and reduce the occurrence of late-stage Lyme disease complications.
Poor Sleep Quality Shown for Lyme Disease Patients
This is the first study to examine and quantify sleep quality in the context of well-defined early Lyme disease (LD) and post-treatment Lyme disease syndrome (PTLDS). The findings provide support that sleep disturbance should be considered in the clinical picture of individuals with LD. Sleep quality may particularly be poor and associated with the pain experience for individuals with PTLDS. Future research will need to validate and expand upon these findings to investigate sleep quality in individuals exposed to LD who are not well-defined and/or ideally treated.
GRASPing the Factors associated with Severe Scleroderma in African Americans
We report results from analysis of clinical, laboratory and socio-demographic data provided by the GRASP cohort, which has enhanced our knowledge about factors associated with significant manifestations of scleroderma in African Americans.
